Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG)

Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG) [Turk J Hematol]

Turk J Hematol. 2022; 39(3): 170-177 | DOI: 10.4274/tjh.galenos.2022.2022.0052

Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG)

�m�r Kay�k��¹, �zg�r Mehtap², �smail Sar�³, Fatih Demirkan⁴, Cengiz Beyan⁵, G�ven �etin⁶, Filiz Vural⁷, Mehmet Y�lmaz⁸, Erman �zt�rk⁹, Seval Akp�nar¹⁰, B�lent Eser¹¹, Mehmet G�nd�z¹², Yahya B�y�ka��k¹³, Bahriye Payzin¹⁴, Rah�an Y�ld�r�m¹⁵, Mehmet Hilmi Do�u¹⁶, Atilla �zkan¹⁷, Engin Kelkitli¹⁸, Emre Tekg�nd�z¹
¹Memorial Bah�elievler Hospital, Clinic of Hematology, �stanbul, Turkey
²Kocaeli University Faculty of Medicine, Department of Hematology, Kocaeli, Turkey
³Memorial Ata�ehir Hospital, Clinic of Hematology, �stanbul, Turkey
⁴Dokuz Eyl�l University Faculty of Medicine, Division of Hematology, �zmir, Turkey
⁵Ufuk University Faculty of Medicine, Division of Hematology, Ankara, Turkey
⁶Bezmialem Vak�f University Faculty of Medicine, Department of Hematology, �stanbul, Turkey
⁷Ege University Faculty of Medicine, Department of Hematology, �zmir, Turkey
⁸Sanko University Faculty of Medicine, Department of Hematology, Gaziantep, Turkey
⁹Medeniyet University Training and Research Hospital, Clinic of Hematology, �stanbul, Turkey
¹⁰Nam�k Kemal University Faculty of Medicine, Department of Hematology, Tekirda�, Turkey
¹¹Medical Park Hospital, Clinic of Hematology, �stanbul, Turkey
¹²Biruni University Hospital, Clinic of Hematology, �stanbul, Turkey
¹³Hacettepe University Faculty of Medicine, Department of Hematology, Ankara, Turkey
¹⁴�zmir Katip �elebi University Atat�rk Training and Research Hospital, Clinic of Hematology, �zmir, Turkey
¹⁵�stinye University Faculty of Medicine, Department of Hematology, �stanbul, Turkey
¹⁶Liv Hospital, Clinic of Hematology, �stanbul, Turkey
¹⁷Yeditepe University Hospital, Clinic of Hematology, �stanbul, Turkey
¹⁸Ondokuz May�s University Faculty of Medicine, Department of Hematology, Samsun, Turkey

Objective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL.
Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016.
Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and eventfree survival rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033, respectively).
Conclusion: The retrospective analysis of a large volume of real-life data on the Turkish experience regarding non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts with some minor differences in terms of survival and transplantation outcomes. The long-term outcome of patients who receive autologous hematopoietic cell transplantation as part of upfront consolidation or salvage therapy is favorable compared to patients who are unable to receive high-dose therapy.

Keywords: Lymphomas, Autologous stem cell transplantation, T-cell lymphomas, Non-Hodgkin lymphoma

Non-kutan�z Periferik T-h�creli Lenfomalarda Klinik �zellikler ve Tedavi Sonu�lar�na ili�kin Ger�ek Ya�am Deneyimi: T�rk Hematoloji Ara�t�rma ve E�itim Grubunun �ok Merkezli �al��mas�

Ama�: Periferik T-h�creli lenfomalar (PTHL) nadir g�r�len, olduk�a heterojen bir grup hastal�kt�r ve t�m non-Hodgkin lenfomalar�n sadece %10-15�ini olu�turur. Son y�llarda hem molek�ler hem de klinik �al��malar artm�� olsa da PTHL�ler �zerindeki ger�ek ya�am verileri hakk�nda hala �ok az bilgiye sahibiz. Bu �al��mada, sistemik, kutan�z olmayan PTHL hastalar� i�eren geni� pop�lasyon tabanl� hasta grubunun klinik �zellikleri ve tedavi sonu�lar�n� ara�t�rmay� ama�lad�k.
Gere� ve Y�ntem: 2008 ve 2016 y�llar� aras�nda kutan�z olmayan PTHL tan�s� ile tedavi edilen 190 ard��k hastan�n geriye d�n�k analizini ger�ekle�tirdik.
Bulgular: T�m birinci basamak tedavi kombinasyonlar� dikkate al�nd��nda, genel yan�t oran�; tam remisyon (n=81) %49,4 ve k�smi yan�t (n=27) %16,5 olmak �zere %65,9 saptand�. Be� y�ll�k genel ve olays�z sa�kal�m oranlar�, transplant ve transplant olmayan gruplar aras�nda �nemli �l��de farkl�yd� (s�ras�yla, p<0,01 ve p=0,033).
Sonu�: Kutan�z olmayan PTHL hastalar�yla ilgili geni� geriye d�n�k ger�ek ya�am veri analizini kapsayan T�rkiye deneyimi, sa�kal�m ve transplantasyon sonu�lar� a��s�ndan baz� k��k farklar i�erse de se�ilmemi� di�er PTHL serileriyle benzer sonu�lar g�stermi�tir. Planl� veya kurtarma tedavisinin bir par�as� olarak otolog hematopoietik h�cre transplantasyonu olan hastalar�n uzun d�nem sonu�lar�, y�ksek doz tedavi almayan hastalara k�yasla daha iyiydi.

Anahtar Kelimeler: Lenfomalar, Otolog k�k h�cre nakli, T-h�creli Lenfomalar, Non-Hodgkin lenfoma

�m�r Kay�k��, �zg�r Mehtap, �smail Sar�, Fatih Demirkan, Cengiz Beyan, G�ven �etin, Filiz Vural, Mehmet Y�lmaz, Erman �zt�rk, Seval Akp�nar, B�lent Eser, Mehmet G�nd�z, Yahya B�y�ka��k, Bahriye Payzin, Rah�an Y�ld�r�m, Mehmet Hilmi Do�u, Atilla �zkan, Engin Kelkitli, Emre Tekg�nd�z. Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG). Turk J Hematol. 2022; 39(3): 170-177

Corresponding Author: �m�r Kay�k��, T�rkiye

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