ISSN: 1300-7777 E-ISSN: 1308-5263
Activated Protein C Resistance in Behçet’s Disease [Turk J Hematol]
Turk J Hematol. 2000; 17(2): 73-76

Activated Protein C Resistance in Behçet’s Disease

Hamid Zarrınanbour1, Gökhan Keser2, Aydan Dönmez1, Seçkin Çağırgan1, Fahrettin Oksel2, Kenan Aksu2, Murat Tombuloğlu1
1Department Of Hematology, Faculty Of Medicine, Ege University, İzmir, Turkey
2Department Of Rheumatology, Faculty Of Medicine, Ege University, İzmir, Turkey

We investigated activated protein C resistance (aPCR) using modified activated partial thromboplastin time (aPTT) in 32 patients with Behçet’s disease (BD) and 9 healthy controls. None of the healthy controls were found to have aPCR. However, 11 out of 32 Behçet’s patients (34.3%) were found to have aPCR. The frequency of aPCR was increased to 44.4% among 18 Behçet’s patients having a history of venous thrombosis. In the subgroup of 14 patients without venous thrombosis, aPCR frequency was %22.2. Our findings show that, besides other factors, aPCR may also predispose patients to venous thrombosis in BD. The detection of aPCR, using modified aPTT may serve as a routine screening test to determine the necessity of prophylactic anticoagulation reatment in patients with BD.

Keywords: Behçet’s disease, Activated protein C resistance, Thrombosis.


Hamid Zarrınanbour, Gökhan Keser, Aydan Dönmez, Seçkin Çağırgan, Fahrettin Oksel, Kenan Aksu, Murat Tombuloğlu. Activated Protein C Resistance in Behçet’s Disease. Turk J Hematol. 2000; 17(2): 73-76

Corresponding Author: Hamid Zarrınanbour, Türkiye


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