ISSN: 1300-7777 E-ISSN: 1308-5263
Detection of Epstein Barr Virus in Hodgkin’s Disease in Trakya Region of Turkey; by in Situ Hybridization [Turk J Hematol]
Turk J Hematol. 2002; 19(4): 461-464

Detection of Epstein Barr Virus in Hodgkin’s Disease in Trakya Region of Turkey; by in Situ Hybridization

Aslı Özdil1, Latife Doğanay1, Muzaffer Demir2, Fulya Öz Puyan1, Selçuk Bilgi1
1Department Of Pathology, Medical Faculty, University Of Trakya, Edirne, Turkey
2Department Of Haematology, Medical Faculty, University Of Trakya, Edirne, Turkey

The relation of Epstein-Barr virus (EBV) and Hodgkin’s disease (HD) has been suggested by serologic, epidemiological and molecular biologic studies. According to these studies the incidence of EBV in HD is high. In the present study, the EBV association with HD in Trakya Region of Turkey was investigated. We investigated the presence of EBV in 44 cases of HD. Fluorescein-labelled antisense EBV (EBER-RNA) was performed by in situ hybridization. There were 28 males and 16 females, with a mean age of 40 years (range 4-80 years). Histological subtypes included nodular sclerosis Hodgkin’s disease (NSHD) in 18 (40.9%), mixed cellularity (MCHD) in 16 (36.4%), lymphocyte predominance (LPHD) in 7 (15.9%), and lymphocyte depletion (LDHD) in 3 (6.8%). EBV was expressed in 30 cases (68.2%). High EBV association was found with mixed cellularity 75% and nodular sclerosis 72.2%. In lymphocyte predominance and in lymphocyte depletion cases the EBV positivity was 57.1% and 33.3%, respectively. All of 7 cases, younger than 15 years old, were positive for EBV. HD in Trakya Region showed a high association with EBV as in developing countries. Our findings suggest that EBV plays an important role in the pathogenesis of HD in Turkey.

Keywords: Epstein-Barr virus, Hodgkin’s disease, In situ hybridization.


Aslı Özdil, Latife Doğanay, Muzaffer Demir, Fulya Öz Puyan, Selçuk Bilgi. Detection of Epstein Barr Virus in Hodgkin’s Disease in Trakya Region of Turkey; by in Situ Hybridization. Turk J Hematol. 2002; 19(4): 461-464, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar


 



Impact Factor (2016) = 0.686