ISSN: 1300-7777 E-ISSN: 1308-5263
Natural Inhibitors and Lipids in Patients with Sickle Cell Disease [Turk J Hematol]
Turk J Hematol. 2000; 17(3): 119-122

Natural Inhibitors and Lipids in Patients with Sickle Cell Disease

Duran Canatan, Nurgül Oğuz, Ahmet Özsancak, İbrahim Aslan, Aynur Bengü, Alim Gürman, Bekir Sarıca
Thalassemia Center, State Hospital Of Antalya, Antalya, Turkey

Microvascular occlusion in sickle cell disease (SCD) is a multifactorial process. Disordered coagulation may play a role in the pathogenesis of vaso occlusive crisis (VOC). The aim of this study was to evaluate the patients and to investigate their Protein C (PC), Protein S (PS) and AT-III levels during normal and crisis periods. A total of 18 patients with SCD were included in this study at the Antalya State Hospital, Thalassemia Center. The mean number of VOC episodes of the patients per year was 4.1 – 3.2. Complications in patients included 4 cases of osteonecrosis (23.5%), 2 cases of holealithiasis (11.7%), 2 cases of leg ulcers (11.7%), and 3 splenectomies (17.6%). The patients during noncrisis periods have lower cholesterol and higher triglycerides levels than the controls (p< 0.001). Hepatic and renal functions were normal in all patients. The mean totals of the PS, PC and AT-III levels were statistically lower both in non crisis and in crisis periods than the control (p< 0.001), but there was no statistical difference between the levels durining noncrisis and crisis periods. In conclusion, PC, PS and AT-IIII deficiencies in patients with SCD are certain. However, these deficiencies do not change during noncrisis and crisis situations and does not play a role on the period of crisis. Abnormal lipid patterns may be a predisposing condition for a crisis.

Keywords: Sickle cell disease, Natural inhibitors, Lipids.


Duran Canatan, Nurgül Oğuz, Ahmet Özsancak, İbrahim Aslan, Aynur Bengü, Alim Gürman, Bekir Sarıca. Natural Inhibitors and Lipids in Patients with Sickle Cell Disease. Turk J Hematol. 2000; 17(3): 119-122

Corresponding Author: Duran Canatan, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar


 



Impact Factor (2017) = 0.650