ISSN: 1300-7777 E-ISSN: 1308-5263
Prognostic significance of wilms tumor 1 gene in childhood acute Lymphoblastic Leukemia [Turk J Hematol]
Turk J Hematol. 2000; 17(4): 183-188

Prognostic significance of wilms tumor 1 gene in childhood acute Lymphoblastic Leukemia

Ünsal Özgen1, Sema Anak1, Uğur Özbek2, Nazan Sarper1, Ertuğrul Eryılmaz1, Leyla Ağaoğlu1, Ömer Devecioğlu1, Nevin Yalman1, Gündüz Gedikoğlu1
1Department Of Pediatric Hematology/oncology, Our Children Leukemia Foundation-pediatric Hematology/oncology And Bone Marrow Transplantation Unit Of İstanbul Medical Faculty İstanbul, Turkey
2Department Of Genetics, Institute For Experimental Medicine (detae), İstanbul University, İstanbul, Turkey

Wilms tumor 1 (WT1) gene is a tumor supressor gene, expressed in malignant and normal hematopoietic progenitor cells. Prognostic significance of this gene in childhood acute lymphoid leukemia (ALL) is not clear. We evaluated the presence of WT1 expression in bone marrow samples of 28 children with de novo ALL at diagnosis by two step RT-PCR. Expression of WT1 gene was detected in 78.5% of patients. There was no correlation between WT1 gene expression and age, sex, FAB type, leukocyte count, and presence of t(4;11) and t(9;22). All patients were treated with modified BFM 86 protocol. There was no difference in the complete remission (CR) rate between WT1 positive and negative patients. Event free survival (EFS) and overall survival (OS) of WT1 positive and negative patients were also not significant. We conclude that expression of WT1 gene is not associated with specific characteristics of ALL blast cells and is not a prognostic factor for CR, remission duration and overall survival.

Keywords: Acute lymphoblastic leukemia, Childhood, Prognosis, Wilms tumor 1 gene.


Ünsal Özgen, Sema Anak, Uğur Özbek, Nazan Sarper, Ertuğrul Eryılmaz, Leyla Ağaoğlu, Ömer Devecioğlu, Nevin Yalman, Gündüz Gedikoğlu. Prognostic significance of wilms tumor 1 gene in childhood acute Lymphoblastic Leukemia. Turk J Hematol. 2000; 17(4): 183-188

Corresponding Author: Ünsal Özgen, Türkiye


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