ISSN: 1300-7777 E-ISSN: 1308-5263
Does von Willebrand Factor Have an Effect on the Occurrence of the Diabetic Complications? [Turk J Hematol]
Turk J Hematol. 2002; 19(1): 31-37

Does von Willebrand Factor Have an Effect on the Occurrence of the Diabetic Complications?

Gürhan Kadıköylü1, A. Zahit Bolaman1, H. Meltem Sönmez1, Meltem Oge1, Engin Güney1, Ali Akyol2, Semra Dündar3, Taşkın Şentürk1
1Department Of Internal Medicine, Medical School, University Of Adnan Menderes, Aydın, Turkey
2Department Of Neurology, Medical School, University Of Adnan Menderes, Aydın, Turkey
3Department Of Ophtalmology, Medical School, University Of Adnan Menderes, Aydın, Turkey

It has been reported that von Willebrand factor (vWf) plays a role in the development of complications of diabetes mellitus. The relationships between vWf and polyneuropathy, nephropathy, and retinopathy were investigated in the patients with type 2 diabetes mellitus. 58 patients with type 2 diabetes mellitus (22 men and 36 women, mean age 54 ± 9 ) and 30 healthy nondiabetic controls (12 men and 18 women, mean age 40 ± 11) were admitted to this study. They were examined by an internist, a neurologist and an ophtalmologist for complications of diabetes mellitus. Electromyography was performed to all the patients. The mean vWf levels of the patients and control group were 1.48 ± 0.55 and 1.25 ± 0.32 IU/mL respectively. There was no significant difference between the two groups (p= 0.146). Diabetic retinopathy in 18 patients (31%), polyneuropathy in 20 patients (34.5%), trap neuropathy in 5 patients (8.6%), microalbuminuria in 9 patients (15.5%), macroalbuminuria in 2 patients (3.5%) and normoalbuminuria in 47 patients (81%) were detected. The difference between vWf levels of the patients with retinopathy and without retinopathy were not statistically significant (p= 0.913). There was no significant difference between patients with polyneuropathy and without polyneuropathy group (p= 0.737). There was also no difference between trap neuropathy and without trap neuropathy (p= 0.431), and between polyneuropathy and trap neuropathy (p= 0.246) patient subgroups. The vWf levels in normoalbuminuric, microalbuminuric and macroalbuminuric patient groups were not different (p values: 0.526, 0.392 and 0.759 respectively). vWf levels between patients with complications of diabetes mellitus and control group were not different (p> 0.05). There was not a significant correlation between the vWf level and body mass index, serum glucose, triglycerides, total cholesterol, HDL-C, LDL-C, VLDL-C, platelet counts, fibrinogen levels, prothrombin and activated thromboplastin times in 33 patients with any complication of diabetes mellitus (p> 0.05). We conclude that, vWf has not an effect in the development of complications in patients with diabetes mellitus.

Keywords: Diabetic complications, von Willebrand factor (vWf).


Gürhan Kadıköylü, A. Zahit Bolaman, H. Meltem Sönmez, Meltem Oge, Engin Güney, Ali Akyol, Semra Dündar, Taşkın Şentürk. Does von Willebrand Factor Have an Effect on the Occurrence of the Diabetic Complications?. Turk J Hematol. 2002; 19(1): 31-37

Corresponding Author: Gürhan Kadıköylü, Türkiye


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