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Prevalence of Beta Thalassemia Trait in Denizli [Turk J Hematol]
Turk J Hematol. 2001; 18(2): 85-88

Prevalence of Beta Thalassemia Trait in Denizli

Zahit Bolaman1, Yaşar Enli2, Mehmet Köseoğlu2, Hasan Koyuncu3, Diler Aslan2
1Department Of Hematology-oncology, School Of Medicine, Adnan Menderes University, Aydın
2Department Of Biochemistry, School Of Medicine, Pamukkale University, Denizli
3Laboratuary Of Genetics, Ministry Of Health Denizli Branch, Denizli, Turkey

Beta thalassemia, characterized by the deficiency or the absence of beta globulin production, is the most widespread inherited disorder in the world and is also common in Turkey. To determine the prevalence of carriers for beta thalassemia, we screened the couples before their marriage. For this aim, from 1994 to 1999, a total of 14.200 people were screened. The complete blood count and red blood cell indices (hemoglobin: Hb, hematocrite: Hct, median corpusculer volume: MCV, median corpusculer hemoglobin: MCHb, median corpusculer hemoglobin concentration: MHbC, concentration were measured by automated cell counter on the same day of collection. Then for the samples with MCV values of 78 fL or below, hemoglobin electrophoresis were employed. Testing for beta thalassemia was carried out by the conventional cellulose asetate electropheresis
at pH 8.4. People who have elevated HbA2 (≥ 3.5%) were accepted as beta-thalassemia carrier or patient. We detected 3300 people with MCV levels of 78 fL or below and 311 cases of beta thalassemia carrier and 11 cases of beta thalassemia. The prevalence of carriers for beta thalassemia in Denizli was 2.2%. This result indicated that the people with anemia in our region should be investigated for the existence of hemoglobinopathy.

Keywords: Anemia, Beta thalassemia, Prevalence, Hemoglobinopathy.

Zahit Bolaman, Yaşar Enli, Mehmet Köseoğlu, Hasan Koyuncu, Diler Aslan. Prevalence of Beta Thalassemia Trait in Denizli. Turk J Hematol. 2001; 18(2): 85-88

Corresponding Author: Zahit Bolaman, Türkiye

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