ISSN: 1300-7777 E-ISSN: 1308-5263
A Rare Complication Developing After Hematopoietic Stem Cell Transplantation: Wernicke’s Encephalopathy [Turk J Hematol]
Turk J Hematol. 2015; 32(4): 367-370 | DOI: 10.4274/tjh.2014.0412  

A Rare Complication Developing After Hematopoietic Stem Cell Transplantation: Wernicke’s Encephalopathy

Soner Solmaz1, Çiğdem Gereklioğlu2, Meliha Tan3, Şenay Demir4, Mahmut Yeral1, Aslı Korur2, Can Boğa1, Hakan Özdoğu1
1Adana Hospital of Başkent University, Department of Hematology, Adana, Turkey
2Adana Hospital of Başkent University, Department of Family Medicine, Adana, Turkey
3Adana Hospital of Başkent University, Department of Neurology, Adana, Turkey
4Adana Hospital of Başkent University, Department of Radiology, Adana, Turkey

Thiamine is a water-soluble vitamin. Thiamine deficiency can present as a central nervous system disorder known as Wernicke’s encephalopathy, which classically manifests as confusion, ataxia, and ophthalmoplegia. Wernicke’s encephalopathy has rarely been reported following hematopoietic stem cell transplantation. Herein, we report Wernicke’s encephalopathy in a patient with acute myeloid leukemia who had been receiving prolonged total parenteral nutrition after haploidentical allogeneic hematopoietic stem cell transplantation. To the best of our knowledge, this is the first case reported from Turkey in the literature.

Keywords: Thiamine, Wernicke’s encephalopathy, Hematopoietic stem cell transplantation, Total parenteral nutrition


Hematopoetik Kök Hücre Nakli Sonrası Gelişen Nadir Bir Komplikasyon: Wernicke Ensefalopatisi

Soner Solmaz1, Çiğdem Gereklioğlu2, Meliha Tan3, Şenay Demir4, Mahmut Yeral1, Aslı Korur2, Can Boğa1, Hakan Özdoğu1
1Adana Hospital of Başkent University, Department of Hematology, Adana, Turkey
2Adana Hospital of Başkent University, Department of Family Medicine, Adana, Turkey
3Adana Hospital of Başkent University, Department of Neurology, Adana, Turkey
4Adana Hospital of Başkent University, Department of Radiology, Adana, Turkey

Tiamin suda çözünen bir vitamindir. Tiamin eksikliği Wernicke ensefalopatisi olarak bilinen, klasik olarak konfüzyon, ataksi ve oftalmopleji ile kendini gösteren bir merkezi sinir sistemi hastalığı olarak karşımıza çıkabilir. Hematopoetik kök hücre nakli sonrasında gelişen Wernicke ensefalopatisi nadiren bildirilmiştir. Bu nedenle haploidentik allojenik kök hücre naklinden sonra uzun süre total parenteral beslenme alan akut myeloid lösemili bir hastada gelişen Wernicke ensefalopatisini sunmak istedik. Bildiğimiz kadarıyla literatürde Türkiye’den bildirilen ilk olgudur.

Anahtar Kelimeler: Tiamin, Wernicke ensefalopatisi, Hematopoetik kök hücre nakli, Total parenteral beslenme


Soner Solmaz, Çiğdem Gereklioğlu, Meliha Tan, Şenay Demir, Mahmut Yeral, Aslı Korur, Can Boğa, Hakan Özdoğu. A Rare Complication Developing After Hematopoietic Stem Cell Transplantation: Wernicke’s Encephalopathy. Turk J Hematol. 2015; 32(4): 367-370

Corresponding Author: Soner Solmaz, Türkiye


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