ISSN: 1300-7777 E-ISSN: 1308-5263
A Case Report: Large Granular Cell Leukemia/Lymphoma (LGL) [Turk J Hematol]
Turk J Hematol. 2002; 19(4): 473-476

A Case Report: Large Granular Cell Leukemia/Lymphoma (LGL)

Orhan Türken1, Ahmet Öztürk1, Bülent Orhan2, Gökhan Kandemir1, Mustafa Yaylacı1
1Department Of Hematology And Oncology, Gülhane Military Medical Academiy, Haydarpaşa Training Hospital, İstanbul, Turkey
2Ali Osman Sönmez Oncology Hospital, İstanbul, Turkey

We presented a 64-year-old male patient with T-large granular cell leukemia/lymphoma with an agressive clinical course. Large granular lymphocytes were noted on peripheral blood smear. The phenotyping of the cells was typical T-cell lineage [CD2 (+), CD3 (+), CD5 (+)]. Clonal rearrangement of the T-cell receptor gene (TCR) was demonstrated by DNA hybridization technique. Large granular cell leukemia/lymphoma is a distinct entity with spesific clinicobiological aspects. The clinical spectrum is wide and immunophenotyping and genotyping studies need to make a diagnosis.

Keywords: Leukemia, Large granular.

Orhan Türken, Ahmet Öztürk, Bülent Orhan, Gökhan Kandemir, Mustafa Yaylacı. A Case Report: Large Granular Cell Leukemia/Lymphoma (LGL). Turk J Hematol. 2002; 19(4): 473-476

Corresponding Author: Orhan Türken, Türkiye

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