ISSN: 1300-7777 E-ISSN: 1308-5263
Epstein-Barr Virus Latent Membrane Protein 1 (LMP-1) in Hodgkin’s Lymphoma Patients in Turkey [Turk J Hematol]
Turk J Hematol. 2001; 18(2): 123-126

Epstein-Barr Virus Latent Membrane Protein 1 (LMP-1) in Hodgkin’s Lymphoma Patients in Turkey

Ömür Ataoðlu1, Turgay Fen2, Özlem Süer1, Mehmet Daðlý2, Zeynep Aký3, Kadri Yamaç4
1Department Of Pathology, Faculty Of Medicine, Gazi University
2Oncology Hospital
3Department Of Hematology, Numune Hospital
4Department Of Hematology, Faculty Of Medicine, Gazi University, Ankara, Turkey

Epstein-Barr virus (EBV) has been implicated as a contributing factor in the development of Hodgkin’s lymphoma. The aim of this study was to elucidate the association of Hodgkin’s lymphoma with EBV in a Turkish population using immunohistochemical detection of LMP-1. We studied a total of 21 consecutive cases of Hodgkin’s lymphoma from Turkey. LMP-1 protein was detected in 9 of 21 (42.8%) cases. LMP-1 was positive
in 4 of 7 (57%) mixed cellularity and 5 of 13 (38.4%) nodular sclerosis subtype. The results of the current study suggests a strong association of Epstein-Barr virus with Hodgkin’s lymphoma in Turkey and, together with those reported previously showed that Epstein-Barr virus correlated with mixed cellular type, with a slight male predominancy while there was no correlation with age.

Keywords: Epstein-Barr virus, Hodgkin’s lymphoma, Latent membrane protein 1.


Ömür Ataoðlu, Turgay Fen, Özlem Süer, Mehmet Daðlý, Zeynep Aký, Kadri Yamaç. Epstein-Barr Virus Latent Membrane Protein 1 (LMP-1) in Hodgkin’s Lymphoma Patients in Turkey. Turk J Hematol. 2001; 18(2): 123-126

Corresponding Author: Kadri Yamaç, Türkiye


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Impact Factor (2017) = 0.650