Rapid progression of acquired amegakaryocytic thrombocytopenia to myelodysplastic syndrome: case reportMehmet Ali Erkurt1, Emin Kaya1, Murat Baran2, Ece Yitmen2, Soner Şenel2, İrfan Kuku1, İsmet Aydoğdu11Department Of Hematology, İnönü University School Of Medicine, Malatya, Turkey
2Department Of Internal Medicine, İnönü University School Of Medicine, Malatya, Turkey
Acquired amegakaryocytic thrombocytopenia (AAT) is a rare disease characterized by severe thrombocytopenia due to selective reduction or absence of megakaryocytes in the bone marrow. More commonly, patients with AAT have additional hematologic abnormalities such as macrocytosis or dyserythropoiesis, abnormalities which may predict progression to aplastic anemia or myelodysplasia. A 52-year-old female was admitted to hospital with mucosal and gingival bleeding. Megakaryocytes were not seen on the bone marrow aspiration and biopsy. AAT was diagnosed. Although she was treated with immunosuppressive therapy including prednisolone and cyclosporine, her disease progressed to myelodysplastic syndrome. She died at the third month of diagnosis because of cerebral bleeding. Keywords: Acquired amegakaryocytic thrombocytopenia, Myelodysplastic syndrome.
Akkiz amegakaryositik trombositopeninin miyelodisplastik sendroma hızlı dönüşümü: Olgu sunumuMehmet Ali Erkurt1, Emin Kaya1, Murat Baran2, Ece Yitmen2, Soner Şenel2, İrfan Kuku1, İsmet Aydoğdu11Department Of Hematology, İnönü University School Of Medicine, Malatya, Turkey
2Department Of Internal Medicine, İnönü University School Of Medicine, Malatya, Turkey
Kazanılmış amegakaryositik trombositopeni kemik iliğinde megakaryositlerin yokluğu ve periferde izole trombositopeni ile seyreden nadir bir hastalıktır. Kazanılmış amegakaryositik trombositopenili hastalara sıklıkla makrositozis ve diseritropoezis gibi hematolojik anormallikler eşlik eder. Bu anormallikler aplastik anemi ve miyelodisplazi gelişiminin habercisi olabilir. Elli iki yaşındaki kadın hasta mukoza ve diş eti kanamasıyla başvurdu. Kemik iliği aspirasyon ve biyopsi incelenmesinde megakaryositlerin görülmemesi üzerine kazanılmış amegakaryositik trombositopeni tanısı kondu. immünsüpresif tedaviye (prednizolon ve siklosporin) cevap vermeyen hastada miyelodisplastik sendrom gelişti. Hasta tanıdan üç ay sonra intrakranial kanama nedeniyle öldü. Anahtar Kelimeler: Kazanılmış amegakaryositik trombositopeni, Miyelodisplastik sendrom.
Mehmet Ali Erkurt, Emin Kaya, Murat Baran, Ece Yitmen, Soner Şenel, İrfan Kuku, İsmet Aydoğdu. Rapid progression of acquired amegakaryocytic thrombocytopenia to myelodysplastic syndrome: case report. Turk J Hematol. 2005; 22(4): 205-208
Corresponding Author: Mehmet Ali Erkurt, Türkiye |
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