ISSN: 1300-7777 E-ISSN: 1308-5263
Bone marrow necrosis in a patient with non-Hodgkin lymphoma [Turk J Hematol]
Turk J Hematol. 2004; 21(2): 97-100

Bone marrow necrosis in a patient with non-Hodgkin lymphoma

Dilek Argon1, Mustafa Çetiner1, Cafer Adıgüzel1, Işık Kaygusuz1, Tülin F. Tuğlular1, Tülay Tecimer2, Mahmut Bayık1
1Department Of Hematology, Marmara University Medical Faculty, Istanbul, Turkey
2Department Of Pathology, Marmara University Medical Faculty, Istanbul, Turkey

Bone marrow necrosis is a rare but ominous finding in various malignant and nonmalignant disorders. It is usually a postmortem diagnosis, but with the advent of modern imaging methods and clinical suspicion, bone marrow necrosis can be diagnosed as antemortem, especially in malignant disorders. We report a 60-years old man with newly diagnosed non-Hodgkin lymphoma presenting with anemia and very high level of alkaline phosphatase. On bone marrow biopsy, it was noted with extensive BMN characterized by cellular debris with indistinct cellular margin and abnormally eosinophilic staining cytoplasm. Despite the prompt institution of aggressive chemotherapy, one week later, liver function tests gradually deteriorated and the patient succumbed. Given the high mortality rate, when the bone marrow necrosis is suspected especially in a patient with malignancy, disease specific treatment and vigorous supportive measures should be immediately commenced.

Keywords: Bone marrow necrosis, Hematologic malignancy.


Non-Hodgkin lenfomalı bir hastada kemik iliği nekrozu

Dilek Argon1, Mustafa Çetiner1, Cafer Adıgüzel1, Işık Kaygusuz1, Tülin F. Tuğlular1, Tülay Tecimer2, Mahmut Bayık1
1Department Of Hematology, Marmara University Medical Faculty, Istanbul, Turkey
2Department Of Pathology, Marmara University Medical Faculty, Istanbul, Turkey

Kemik iliği nekrozu nadir görülen, kötü prognozlu bir klinik tablodur. Tümöral ve tümör dışı çeşitli nedenlerle olu makla beraber en sık lösemilerde karşılaşılmaktadır. Sunulan olgu, 60 yaşında anemi, iki taraflı servikal lenfadenopatileri ve hepatosplenomegalisi olan, kan tetkiklerinde çok yüksek alkalen fosfataz seviyesi, kemik iliği biyopsisinde silüet şeklinde tipik hücre boyanması ile karakterize görünümüyle yaygın kemik iliği nekrozu saptanan ve agresif tedaviye rağmen kaybedilen Hodgkin-dışı lenfomalı bir hastadır. Bu tip hastaların sağaltımında erken tanının, yoğun bir destek tedavisinin ve altta yatan nedene yönelik agresif tedavinin önemini vurgulamak istiyoruz.

Anahtar Kelimeler: Kemik iliği nekrozu, Hematolojik malignite.


Dilek Argon, Mustafa Çetiner, Cafer Adıgüzel, Işık Kaygusuz, Tülin F. Tuğlular, Tülay Tecimer, Mahmut Bayık. Bone marrow necrosis in a patient with non-Hodgkin lymphoma. Turk J Hematol. 2004; 21(2): 97-100

Corresponding Author: Dilek Argon, Türkiye


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