Acquired pure megakaryocytic aplasia successfully treated with cyclosporineHalima El Omri1, Firyal Ibrahim2, Ruba Yasin Taha1, Riham Hassan Negm1, Aisha Al Khinji1, Mohammed Yassin1, Ibrahim Al Hijji1, Hanadi El Ayoubi1, Hussein Baden21Department Of Laboratory Medicine And Pathology, Al Amal Hospital, Doha, Qatar
2Department Of Hematology And Bone Marrow Transplant, Al Amal Hospital, Doha, Qatar
Acquired pure megakaryocytic aplasia is a rare hematological disorder characterized by thrombocytopenia with absent or markedly reduced megakaryocytes in the bone marrow. We report a case of a 25-year-old male diagnosed as acquired pure megakaryocytic aplasia. Treatment with prednisone and intravenous immunoglobulin failed, but he was successfully treated with cyclosporine, with complete remission after 90 days and normal platelet count maintained thereafter. Keywords: Acquired amegakaryocytic thrombocytopenia, steroids, cyclosporine
Siklosporin ile başarılı şekilde tedavi edilen kazanılmış saf megakaryositik aplaziHalima El Omri1, Firyal Ibrahim2, Ruba Yasin Taha1, Riham Hassan Negm1, Aisha Al Khinji1, Mohammed Yassin1, Ibrahim Al Hijji1, Hanadi El Ayoubi1, Hussein Baden21Department Of Laboratory Medicine And Pathology, Al Amal Hospital, Doha, Qatar
2Department Of Hematology And Bone Marrow Transplant, Al Amal Hospital, Doha, Qatar
Kazanılmış saf megakaryositik aplazi, kemik iliğinde namevcut ya da anlamlı ölçüde azaltılmış megakaryosit içeren trombositopeni ile karakterize, nadir hematolojik bir hastalıktır. Kazanılmış saf megakaryositik aplazi teşhisi konmuş, prednizon ve intravenöz immunoglobulin ile tedavisi başarısız olmuş ve siklosporin ile başarılı biçimde tedavi edilerek 90 gün sonra tam remisyona ulaşan ve ondan sonra platelet sayımı normalleşen 25 yaşında erkek bir olgunun raporu sunulmuştur. Anahtar Kelimeler: Kazanılmış amegakaryositik trombositopeni, steroidler, siklosporin
Halima El Omri, Firyal Ibrahim, Ruba Yasin Taha, Riham Hassan Negm, Aisha Al Khinji, Mohammed Yassin, Ibrahim Al Hijji, Hanadi El Ayoubi, Hussein Baden. Acquired pure megakaryocytic aplasia successfully treated with cyclosporine. Turk J Hematol. 2010; 27(4): 289-293
Corresponding Author: Halima El Omri, Qatar |
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