Impact of Fluorescence in Situ Hybridization in the Detection of Cryptic Fusion Transcript PML/RARA and A Complex t(5;15;17) in a Case of Acute Promyelocytic LeukemiaGönül Ogur1, Turgay Fen2, Gülsan Sucak3, Pierre Heimann1, Gaye Cankuş4, Rauf Haznedar41Univérsité Libre De Bruxelles, Hôpital Erasme, Service Génétique Medicale, Bruxelles, Belgıum
2Oncology Hospital, Ankara, Turkey
3Adult Hematology Department, Faculty Of Medicine, Gazi University, Ankara, Turkey
4Gen-med Genetic Diseases And Prenatal Diagnosis Center, Ankara, Turkey
Genetic aspects of a 28 year-old female patient with typical morphological and clinical features of acute promyelocytic leukemia is presented. Pml/rara fusion transcript and a complex translocation involving chromosomes 5, 15 and 17 were detected by fluorescence in situ hybridization (FISH) technique which was applied as in adjunct to conventional cytogenetics. The patient deceased soon in spite of the immediate ATRA and cytostatic therapy. Keywords: FISH, PML/RARA, Acute promyelocytic leukemia.
Gönül Ogur, Turgay Fen, Gülsan Sucak, Pierre Heimann, Gaye Cankuş, Rauf Haznedar. Impact of Fluorescence in Situ Hybridization in the Detection of Cryptic Fusion Transcript PML/RARA and A Complex t(5;15;17) in a Case of Acute Promyelocytic Leukemia. Turk J Hematol. 2000; 17(4): 207-212
Corresponding Author: Gönül Ogur, Türkiye |
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