ISSN: 1300-7777 E-ISSN: 1308-5263
Immunosuppressive Therapy-Induced Hepatotoxicity in Patients with Aplastic Anemia [Turk J Hematol]
Turk J Hematol. 2000; 17(3): 111-117

Immunosuppressive Therapy-Induced Hepatotoxicity in Patients with Aplastic Anemia

İmdat Dilek1, Ramazan İdilman2, Semin Fenkçi1, Celalettin Üstün1, Haluk Koç1, Osman İlhan1, Hamdi Akan1
1Department Of Hematology, Medical School, University Of Ankara, Ankara, Turkey
2Department Of Gastroenterology, Medical School, University Of Ankara, Ankara, Turkey

Immunosuppressive therapy is a treatment for aplastic anemia patients who are not candidates for hematopoietic stem cell transplantation. The aim of the study to evaluate the frequency and severity of immunosuppressive therapy-induced hepatotoxicity in patients with aplastic anemia. The records of 27 patients with aplastic anemia who had eceived immunosuppressive therapy were received and determined for evidence of hepatotoxicity. The patients were divided into three groups. Group 1 was treated with antithymocyte/antilymphocyte globulin and cyclosporin A, group 2 received onl yyclosporin-A and group 3 was treated with antithymocyte/antilymphocyte globulin + cyclosporin-A and granulocyte macrophage colony-stimulating factor. All patients in group 1 had an initial increase in AST and ALT levels after therapy, but these tests abnormalities returned to normal in each case (p> 0.05). There was no detectable change in AST and ALT levels in group 2 (p>0.05). In group 3, five patients had an increase in ALT and AST levels in the initial several days after therapy was started but he levels gradually returnedto normal by the second or third week of therapy.

Keywords: Aplastic anemia, Hepatotoxicity, Immunosuppressive therapy, Liver, ntithymocyte/antilymphocyte globulin.


İmdat Dilek, Ramazan İdilman, Semin Fenkçi, Celalettin Üstün, Haluk Koç, Osman İlhan, Hamdi Akan. Immunosuppressive Therapy-Induced Hepatotoxicity in Patients with Aplastic Anemia. Turk J Hematol. 2000; 17(3): 111-117

Corresponding Author: İmdat Dilek, Türkiye


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