ISSN: 1300-7777 E-ISSN: 1308-5263
Central Nervous System Involvement of T-cell Prolymphocytic Leukemia Diagnosed with Stereotactic Brain Biopsy: Case Report [Turk J Hematol]
Turk J Hematol. 2014; 31(1): 75-78 | DOI: 10.4274/Tjh.2012.0028  

Central Nervous System Involvement of T-cell Prolymphocytic Leukemia Diagnosed with Stereotactic Brain Biopsy: Case Report

Selçuk Göçmen1, Murat Kutlay2, Alev Erikçi3, Cem Atabey1, Özkan Sayan3, Aptullah Haholu4
1Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department Of Neurosurgery, İstanbul, Turkey
2Gülhane Military Medical Academy, Department Of Neurosurgery, Ankara, Turkey
3Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department Of Hematology, İstanbul, Turkey
4Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department Of Pathology, İstanbul, Turkey

Prolymphocytic leukemia (PLL) is a generalized malignancy of the lymphoid tissue characterized by the accumulation of monoclonal lymphocytes, usually of B cell type. Involvement of the central nervous system (CNS) is an extremely rare complication of T-cell prolymphocytic leukemia (T-PLL). We describe a case of T-PLL presenting with symptomatic infiltration of the brain that was histopathologically proven by stereotactic brain biopsy. We emphasize the importance of rapid diagnosis and immediate treatment for patients presenting with CNS involvement and a history of leukemia or lymphoma.

Keywords: T-cell prolymphocytic leukemia, Cerebral involvement, Central nervous system, Stereotactic biopsy


Stereotaktik Beyin Biyopsisi ile Tanı Koyulan T-hücreli Prolenfositik Löseminin Santral Sinir Sistemi Tutulumu: Olgu Sunumu

Selçuk Göçmen1, Murat Kutlay2, Alev Erikçi3, Cem Atabey1, Özkan Sayan3, Aptullah Haholu4
1Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department Of Neurosurgery, İstanbul, Turkey
2Gülhane Military Medical Academy, Department Of Neurosurgery, Ankara, Turkey
3Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department Of Hematology, İstanbul, Turkey
4Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Department Of Pathology, İstanbul, Turkey

Prolenfositik lösemi (PLL), genellikle B hücre tipi monoklonal lenfositlerin birikimi ile karakterize lenfoid dokunun genel malign bir hastalığıdır. Santral sinir sistemi (SSS) tutulumu T-hücreli Prolenfositik löseminin (T-PLL) çok nadir görülen bir komplikasyonudur. Biz, beyinin semptomatik infiltrasyonu ile ortaya çıkan, stereotaktik beyin biopsisi ile tanı koyulmuş T-PLL’li bir olgu sunuyoruz. Geçmişte lösemi veya lenfoma nedeni ile tedavi edilmiş ve SSS tutulumu ile başvuran hastalar için, hızlı tanı ve acil tedavinin önemini açıkladık.

Anahtar Kelimeler: T-hücreli prolenfositik lösemi, Serebral tutulum, Santral sinir sistemi, Stereotaktik biyopsi


Selçuk Göçmen, Murat Kutlay, Alev Erikçi, Cem Atabey, Özkan Sayan, Aptullah Haholu. Central Nervous System Involvement of T-cell Prolymphocytic Leukemia Diagnosed with Stereotactic Brain Biopsy: Case Report. Turk J Hematol. 2014; 31(1): 75-78

Corresponding Author: Selçuk Göçmen, Türkiye


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