Turk J Hematol. 2004; 21(1): 45-48

A Case with Chronic Eosinophilic Leukaemia Resulting in Blastic Transformation

Abdullah Hacıhanefioğlu¹, Muharrem Akkaş², Pınar Tarkun², A. Turgut Karakaya², Cengiz Erçin^3
1Department Of Haematology, Kocaeli University Medical Faculty, Kocaeli, Turkey
²Department Of Internal Medicine, Kocaeli University Medical Faculty, Kocaeli, Turkey
³Department Of Pathology, Kocaeli University Medical Faculty, Kocaeli, Turkey

Chronic eosinophilic leukaemia is a rare myeloproliferative disease different from the chronic myeloid leukaemia. It is a haematologic malignancy that must be considered separately from other causes of eosinophilia due to its remarkable clonal eosinophilia. Here, we describe a case with chronic eosinophilic leukaemia which was initially hypereosinophilic (eosinophil count: 85.4 x 109/L) and displayed blastic transformation after a 9 months follow up. We suggest the invasion of spleen, probable invasion of the liver and the blastic transformation of this case must be discerned as a different entity rather than the other causes of eosinophilia.

Keywords: Eosinophilic, Hypereosinophilic syndrome, Eosinophilic leukaemia, chronic.

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Miyeloblastik Transformasyonla Sonlanan Kronik Eozinofilik Lösemi Olgusu

Abdullah Hacıhanefioğlu¹, Muharrem Akkaş², Pınar Tarkun², A. Turgut Karakaya², Cengiz Erçin^3
1Department Of Haematology, Kocaeli University Medical Faculty, Kocaeli, Turkey
²Department Of Internal Medicine, Kocaeli University Medical Faculty, Kocaeli, Turkey
³Department Of Pathology, Kocaeli University Medical Faculty, Kocaeli, Turkey

Kronik eozinofilik lösemi (CEL) nadir görülen ve kronik miyeloid lösemiden farklı miyeloproliferatif bir hastalıktır. Klonal eozinofil artışı nedeniyle diğer eozinofili nedenlerinden ayrı ele alınması gereken hematolojik bir malignitedir. Burada hipereozinofili ile seyreden (eozinofil sayısı: 85.4x109/L) ve takibe alındıktan dokuz ay sonra blastik transformasyon gösteren bir kronik eozinofilik lösemi olgusu sunmaktayız. Bu tablonun dalak tutulumu, muhtemel karaciğer tutulumu ve blastik transformasyonla sonlanması nedeni ile diğer eozinofili nedenlerinden ayırdedilmesi gerektiğini düşünüyoruz.

Anahtar Kelimeler: Eozinofili, Hipereozinofilik sendrom, Eozinofilik lösemi, kronik.

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