ISSN: 1300-7777 E-ISSN: 1308-5263
Late Endocrine Side Effects in Children with Acute Leukemia [Turk J Hematol]
Turk J Hematol. 2007; 24(1): 8-13

Late Endocrine Side Effects in Children with Acute Leukemia

Mustafa Büyükavcı1, Nazan Çetingül1, Şükran Darcan2, Mehmet Kantar1, Kaan Kavaklı3
1Deparment Of Pediatric Oncology, Ege University, Faculty Of Medicine, İzmir, Turkey
2Deparment Of Pediatric Endocrinology, Ege University, Faculty Of Medicine, İzmir, Turkey
3Deparment Of Pediatric Hematology, Ege University, Faculty Of Medicine, İzmir, Turkey

This study was carried out in 28 patients (10 female, 18 male) diagnosed with acute leukemia, and aimed to investigate the abnormalities of endocrine system. Twenty-five of 28 patients were acute lymphoblastic leukemia and 3 were acute non-lymphocytic leukemia. Sixteen children were treated using BFM-90 chemotherapy protocol, and the rest with various regimens. Two patients were exposed to 12-13 Gy of total body irradiation followed by bone marrow transplantation. All patients were in remission at least five years. One (3%) of 28 patients had short stature and 4 (14%) had obesity. Pubertal status was retarded in 2 (7%) patients. Glucose intolerance, secondary hypothyroidism and hypergonadotropic hypogonadism were detected in 2, 1 and 2 patients, respectively. TSH response to TRH test was exaggerated in 1 and blunted in 3 patients.

Keywords: Children, acute leukemia, endocrine, late side effects


Akut lösemili çocuklarda geç endokrin yan etkiler

Mustafa Büyükavcı1, Nazan Çetingül1, Şükran Darcan2, Mehmet Kantar1, Kaan Kavaklı3
1Deparment Of Pediatric Oncology, Ege University, Faculty Of Medicine, İzmir, Türkiye
2Deparment Of Pediatric Endocrinology, Ege University, Faculty Of Medicine, İzmir, Türkiye
3Deparment Of Pediatric Hematology, Ege University, Faculty Of Medicine, İzmir, Türkiye

Bu çalışmaya akut lösemi tanısı almış ve en az 5 yıldır remisyonda olan 28 hasta (10 kız, 18 erkek) dahil edildi ve bu olgularda endokrin yan etkiler araştırıldı. Yirmibeş hasta akut lenfoblastik lösemi, 3 hasta akut non-lenfositik lösemi tanısı almıştı. Onaltı çocuğun tedavisinde BFM-90 tadavi protokolü kullanılırken diğerleri farklı tedavi rejimleri aldılar. İki hastaya 12-13 Gy total vücut ışınlaması sonrası kemik iliği transplantasyonu uygulandı. Yirmisekiz hastadan birinde (%3) boy kısalığı, dördünde (%14) obezite mevcuttu. Hastaların ikisinde (%7) gecikmiş puberte, ikisinde glukoz intoleransı, birinde sekonder hipotroidizm ve ikisinde de hipergonadotropik hipogonadizm saptandı. Bir olguda TRH testine abartılı TSH yanıtı, 3 olguda baskılanmış yanıt gözlendi.

Anahtar Kelimeler: Çocuklar, akut lösemi, endokrin, geç yan etki


Mustafa Büyükavcı, Nazan Çetingül, Şükran Darcan, Mehmet Kantar, Kaan Kavaklı. Late Endocrine Side Effects in Children with Acute Leukemia. Turk J Hematol. 2007; 24(1): 8-13

Corresponding Author: Mustafa Büyükavcı, Türkiye


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