ISSN: 1300-7777 E-ISSN: 1308-5263
The Levels of Sera Malondialdehyde, Erythrocyte Membrane Na+-K+/Mg++ and Ca++/Mg++ Adenosine 5’ Triphosphatase in Patients with Sickle Cell Anemia [Turk J Hematol]
Turk J Hematol. 2000; 17(1): 23-26

The Levels of Sera Malondialdehyde, Erythrocyte Membrane Na+-K+/Mg++ and Ca++/Mg++ Adenosine 5’ Triphosphatase in Patients with Sickle Cell Anemia

Lülüfer Tamer1, Gürbüz Polat1, Güzide Yücebilgiç2, Birol Güvenç3, Fikri Başlamışlı3
1Department Of Biochemistry, Faculty Of Medicine, University Of Mersin, Mersin, Turkey
2Department Of Biochemistry, Faculty Of Arts And Science, University Of Çukurova, Adana, Turkey
3Department Of Hematology, Faculty Of Medicine, University Of Çukurova, Adana, Turkey

The various membrane abnormalities of sickle erythrocytes may result from excessive accumulation of oxidant damage. We measured the sera levels of malondialdehyde, products of lipid peroxidation, Na+-K+/Mg++ Adenosine 5’ triphosphatase (ATPase) and Ca++/Mg++ Adenosine 5’ triphosphatase, erythrocyte membrane enzymes, in patients with sickle cell anemia and compared their levels with that of normal controls. MDA, Na+-K+/Mg++ and Ca++/Mg++ ATPase levels of control groups were 0.90 ± 0.04 nmol/mL, 168 ± 12.9 and 140.6 ± 8.2 nmol Pi/mg prot/hour, respectively. MDA, Na+-K+/Mg++ and Ca++/Mg++ATPase levels of patients were 2.02 ± 0.01 nmol/mL, 127.0 ± 8.4 and 110.0 ± 9.6 nmol Pi/mg prot/hour, respectively. Our experimental results showed that there was a significant increase in MDA levels of patients with sickle cell anemia as compared with that of the controls. However, erythrocyte membrane Na+-K+/Mg++ and Ca++/Mg++ ATPase levels of patients with sickle cell anemia were significantly lower than the, Na+-K+/Mg++ and Ca++/Mg++ ATPase levels of normal controls.

Keywords: MDA, ATPase, Sickle cell.


Lülüfer Tamer, Gürbüz Polat, Güzide Yücebilgiç, Birol Güvenç, Fikri Başlamışlı. The Levels of Sera Malondialdehyde, Erythrocyte Membrane Na+-K+/Mg++ and Ca++/Mg++ Adenosine 5’ Triphosphatase in Patients with Sickle Cell Anemia. Turk J Hematol. 2000; 17(1): 23-26

Corresponding Author: Lülüfer Tamer, Türkiye


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