ISSN: 1300-7777 E-ISSN: 1308-5263
Hemophagocytic syndrome with erythrocyte phagocytosis by the myeloid precursors in a patient with AML -M2 [Turk J Hematol]
Turk J Hematol. 2008; 25(1): 42-44

Hemophagocytic syndrome with erythrocyte phagocytosis by the myeloid precursors in a patient with AML -M2

Mümtaz Yılmaz1, Filiz Vural2, Mahmut Töbü2, Yeşim Ertan3, Filiz Büyük2
1Departments Of Internal Medicine, Ege University, Faculty Of Medicine, İzmir, Turkey
2Departments Of Adult Hematology, Ege University, Faculty Of Medicine, İzmir, Turkey
3Departments Of Pathology, Ege University, Faculty Of Medicine, İzmir, Turkey

Hemophagocytic syndrome is characterized by fever, fatigue, weight loss, lymphadenopathy, and laboratory abnormalities including pancytopenia, liver dysfunction, hypertriglyceridemia and hyperfibrinemia. Histopathologically, lesions are characterized by mononuclear cell infiltration with marked histiocyte proliferation and phagocytosis of erythrocytes, leukocytes, platelets and their precursors by activated macrophages in the reticuloendothelial tissues. Hemophagocytic syndrome may develop from strong immunological stimuli such as severe infection, malignancy and autoimmune diseases.
We present a 73-year-old man with acute myeloblastic leukemia FAB M2 type (AML M2) whose bone marrow histology showed unusual hemophagocytosis by myeloid cells and myeloblasts.

Keywords: Hemophagocytic syndrome, acute myeloblastic leukemia, AML


Myeloid öncül hücreleri ve myeloblastlar tarafından eritroid fagositozu ile seyreden hemopagositik sendromlu AML-M2 olgusu

Mümtaz Yılmaz1, Filiz Vural2, Mahmut Töbü2, Yeşim Ertan3, Filiz Büyük2
1Departments Of Internal Medicine, Ege University, Faculty Of Medicine, İzmir, Turkey
2Departments Of Adult Hematology, Ege University, Faculty Of Medicine, İzmir, Turkey
3Departments Of Pathology, Ege University, Faculty Of Medicine, İzmir, Turkey

Hemofagositik sendrom, ateş, halsizlik, kilo kaybı, lenfadenopati ve pansitopeni, bozulmuş karaciğer fonksiyon testi, hipertriglserdemi, hiperferritinemi ile karakterli klinik tablodur. Histopatolojik olarak, retiküloendotel dokularda histiositten zengin mononükleer hücre infiltrasyonu ve active makrofajlar tarafından eritrosit, lökosit, platelet ve bunların öncül hücrelerinin fagositozları ile karekterlidir. Hemofagositik sendromun, şiddetli enfeksiyon, malign ve otoimmün hastalıklar gibi güçlü immünolojik uyaranlar sonucu geliştiği düşünülmektedir.

Anahtar Kelimeler: Hemofagositik sendrom, akut myeloblastik lösemi, AML


Mümtaz Yılmaz, Filiz Vural, Mahmut Töbü, Yeşim Ertan, Filiz Büyük. Hemophagocytic syndrome with erythrocyte phagocytosis by the myeloid precursors in a patient with AML -M2. Turk J Hematol. 2008; 25(1): 42-44

Corresponding Author: Filiz Vural, Türkiye


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