ISSN: 1300-7777 E-ISSN: 1308-5263
Histopathologic and Immunophenotypic Features of Childhood and Adult Anaplastic Large-Cell Lymphomas [Turk J Hematol]
Turk J Hematol. 2001; 18(4): 265-274

Histopathologic and Immunophenotypic Features of Childhood and Adult Anaplastic Large-Cell Lymphomas

Mine Hekimgil1, Saliha Soydan1, Deniz Nart1, Ali Veral1, Seçkin Çağırgan2, Nazan Çetingül3
1Department Of Pathology, Faculty Of Medicine, University Of Ege, İzmir, Turkey
2Department Of Internal Medicine, Faculty Of Medicine, University Of Ege, İzmir, Turkey
3Department Of Pediatrics, Faculty Of Medicine, University Of Ege, İzmir, Turkey

The t (2;5) (p23; q35) translocation associated with CD30-positive anaplastic large-cell lymphoma (ALCL) creates a hybrid gene encoding the chimeric nucleolar protein nucleophosmin-anaplastic lymphoma kinase (NFMALK) protein, which can be demonstrated by immunostaining with ALK1 monoclonal antibody. In this study, 40 specimens of ALCL from 6 pediatric, 34 adult patients, were immunostained with monoclonal antibodies against CD30 (Ber-H2), EMA, CD45 (LCA), CD3, CD20 (L26), CD15, and ALK1 antigens, and results were correlated with histopathologic features. The mean age of the pediatric and adult patients was 10-years and 38-years, respectively. ALK1 was positive in 14 cases (35%) representing 83% of pediatric and 26% of adult patients, statistically significantly higher in the pediatric group (p= 0.01). Considering the better prognosis attributed to cases with t (2;5), it is interesting to note that the percentage of ALK1-positive cases is significantly higher in pediatric patients with coexpression of EMA, compared to adults.

Keywords: Anaplastic large-cell lymphoma, ALK1, CD30, Epithelial membrane antigen.


Mine Hekimgil, Saliha Soydan, Deniz Nart, Ali Veral, Seçkin Çağırgan, Nazan Çetingül. Histopathologic and Immunophenotypic Features of Childhood and Adult Anaplastic Large-Cell Lymphomas. Turk J Hematol. 2001; 18(4): 265-274, Türkiye


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Impact Factor (2016) = 0.686