ISSN: 1300-7777 E-ISSN: 1308-5263
Asecretory POEMS Syndrome with Widespread Osteosclerotic Lesions [Turk J Hematol]
Turk J Hematol. 2000; 17(2): 81-84

Asecretory POEMS Syndrome with Widespread Osteosclerotic Lesions

Murat Tombuloğlu1, Güray Saydam1, Ayhan Dönmez1, Seçkin Çağırgan1, Mine Hekimgil2, Saliha Soydan2, Mehmet Şencan1, Filiz Büyükkeçeci1
1Department Of Internal Medicine, Hematology Division, Faculty Of Medicine, Ege University, İzmir, Turkey
2Department Of Pathology, Faculty Of Medicine, Ege University, İzmir, Turkey

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) is a rare disease and constitues 1-2% of plasma cell dyscrasia. Most of the patients have few sclerotic bone lesions and more than 90% of patients have serum and/or urinary M-protein. In this report, we present a patient with POEMS syndrome who had severe polyneuropathy and unusual widespread osteosclerotic lesions without M- rotein in serum and urine. According to our knowledge, this is the first case of asecretory POEMS syndrome with multipl sclerotic lesions and polyneuropathy. Our patient is still well and able to work actively 4 years after diagnosis with the treatment of 12 courses of VAD by reducing the vincristine dosage.

Keywords: POEMS syndrome, Asecretory, Osteosclerosis.


Murat Tombuloğlu, Güray Saydam, Ayhan Dönmez, Seçkin Çağırgan, Mine Hekimgil, Saliha Soydan, Mehmet Şencan, Filiz Büyükkeçeci. Asecretory POEMS Syndrome with Widespread Osteosclerotic Lesions. Turk J Hematol. 2000; 17(2): 81-84

Corresponding Author: Murat Tombuloğlu, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar


 



Impact Factor (2017) = 0.650