Asecretory POEMS Syndrome with Widespread Osteosclerotic LesionsMurat Tombuloğlu1, Güray Saydam1, Ayhan Dönmez1, Seçkin Çağırgan1, Mine Hekimgil2, Saliha Soydan2, Mehmet Şencan1, Filiz Büyükkeçeci11Department Of Internal Medicine, Hematology Division, Faculty Of Medicine, Ege University, İzmir, Turkey 2Department Of Pathology, Faculty Of Medicine, Ege University, İzmir, Turkey
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) is a rare disease and constitues 1-2% of plasma cell dyscrasia. Most of the patients have few sclerotic bone lesions and more than 90% of patients have serum and/or urinary M-protein. In this report, we present a patient with POEMS syndrome who had severe polyneuropathy and unusual widespread osteosclerotic lesions without M- rotein in serum and urine. According to our knowledge, this is the first case of asecretory POEMS syndrome with multipl sclerotic lesions and polyneuropathy. Our patient is still well and able to work actively 4 years after diagnosis with the treatment of 12 courses of VAD by reducing the vincristine dosage. Keywords: POEMS syndrome, Asecretory, Osteosclerosis.
Murat Tombuloğlu, Güray Saydam, Ayhan Dönmez, Seçkin Çağırgan, Mine Hekimgil, Saliha Soydan, Mehmet Şencan, Filiz Büyükkeçeci. Asecretory POEMS Syndrome with Widespread Osteosclerotic Lesions. Turk J Hematol. 2000; 17(2): 81-84
Corresponding Author: Murat Tombuloğlu, Türkiye |
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