ISSN: 1300-7777 E-ISSN: 1308-5263
Epstein-Barr Virus in Hodgkin’s Disease Patients in Northeast Anatolia [Turk J Hematol]
Turk J Hematol. 2000; 17(2): 61-65

Epstein-Barr Virus in Hodgkin’s Disease Patients in Northeast Anatolia

Hasan Kaya1, Zekai Erman2, Celal Gündoğdu2, S. Başol Tekin1, Mehmet Gündoğdu1
1Department Of Hematology, Medicine School Of Atatürk University, Erzurum, Turkey
2Department Of Pathology, Medicine School Of Atatürk University, Erzurum, Turkey

Epstein-Barr virus (EBV) is implicated as an etiologic factor in Hodgkin's disease (HD). The proportion of HD patients with EBV is high in developing countries but low in developed countries. In the present study, the EBV association with HD in Northeast Anatolia was investigated. Thirty-six formalin-fixed paraffin-embedded cases of HD were analysed for the presence of EBV and, for the latent membrane protein (LPM-1) by immunohistochemistry. There were 26 males and 10 females; age distribution ranged from 12 to 73 years (mean ± standard deviation, 34.1 ± 15.2 years). Overall, LPM-1 was detected in 27 of the 36 cases (75%). LPM-1 expression varied according to the istological subtype of HD (9/55 cases of lymphocyte predominance subtype, 3/4 cases of nodular sclerosis, 18/18 cases of mixed cellularity subtype, and 1/5 cases of lymphocyte depletion subtype). In this study, the EBV-positivity ratio in HD was found extremely high in Northeast Anatolia.

Keywords: Epstein-Barr virus, Hodgkin's disease, Northeast Anatolia.


Hasan Kaya, Zekai Erman, Celal Gündoğdu, S. Başol Tekin, Mehmet Gündoğdu. Epstein-Barr Virus in Hodgkin’s Disease Patients in Northeast Anatolia. Turk J Hematol. 2000; 17(2): 61-65

Corresponding Author: Hasan Kaya, Türkiye


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Impact Factor (2016) = 0.686