ISSN: 1300-7777 E-ISSN: 1308-5263
Association of HLA class II Alleles and the Occurrence of Factor VIII Inhibitor in Thai Patients with Hemophilia A [Turk J Hematol]
Turk J Hematol. 2012; 29(1): 34-39 | DOI: 10.5505/tjh.2012.29795  

Association of HLA class II Alleles and the Occurrence of Factor VIII Inhibitor in Thai Patients with Hemophilia A

Oytip Nathalang1, Pramote Sriwanitchrak1, Werasak Sasanakul2, Ampaiwan Chuansumrit2
1Department Of Medical Technology, Faculty Of Allied Health Sciences, Thammasat University, Pathumtani, Thailand
2Department Of Pediatrics, Faculty Of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok,thailand

OBJECTIVE: In this study HLA class II alleles were tested to investigate the association with the occurrence of FVIII inhibitor among Thai patients with hemophilia A.
METHODS: The distribution of HLA-DRB1 alleles and DQB1 alleles in 57 Thai patients with hemophilia A was determined using the PCR- sequence specific primer (PCR-SSP) method, and the association between the occurrence of factor VIII (FVIII) inhibitor and the presence of certain HLA class II alleles was investigated.
RESULTS: The frequency of HLA-DRB1* 15 was increased in hemophiliac patients both with and without FVIII inhibitors, whereas those of DRB1* 14, DRB1* 07 and DQB1* 02 were decreased in hemophiliac patients with FVIII inhibitors. Interestingly, only DRB1* 15 was significantly increased in patients with inhibitors compared with the controls (P = 0.021). Moreover, the frequency of DRB1* 15 in patients with inhibitor tended to be higher than patients with non inhibitor (P = 0.198).
CONCLUSION: Our data showed that the DRB1* 15 allele may contribute to the occurrence of inhibitor among Thai hemophilia A patients. However, a larger sample size and high-resolution DRB1 typing are warranted.

Keywords: HLA class II alleles, FVIII inhibitor, Hemophilia A, Thais


Oytip Nathalang, Pramote Sriwanitchrak, Werasak Sasanakul, Ampaiwan Chuansumrit. Association of HLA class II Alleles and the Occurrence of Factor VIII Inhibitor in Thai Patients with Hemophilia A. Turk J Hematol. 2012; 29(1): 34-39

Corresponding Author: Ampaiwan Chuansumrit, Thailand


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