ISSN: 1300-7777 E-ISSN: 1308-5263
Trisomy Chromosome 6 as a Sole Cytogenetic Abnormality in Acute Myeloid Leukemia [Turk J Hematol]
Turk J Hematol. 2015; 32(1): 77-79 | DOI: 10.4274/tjh.2013.0107  

Trisomy Chromosome 6 as a Sole Cytogenetic Abnormality in Acute Myeloid Leukemia

Monika  Gupta, Nita  Radhakrishnan, Manoranjan Mahapatra, Renu Saxena
All India Institute of Medical Sciences, Department of Hematology, New Delhi, India

Identification of cytogenetic abnormalities plays an important role in the diagnosis and prognosis of leukemias. Isolated trisomy 6 is a rare abnormality, the prognostic significance of which is not well established. We report one case of acute myeloid leukemia (AML-M5 variant) with trisomy 6 as the sole cytogenetic abnormality. Previously, trisomy 6 has been reported in aplastic anemia, myelodysplastic syndrome, and AML, usually associated with hypocellular marrow. However, our patient had a very short history and hypercellular marrow infiltrated with blasts. We report this case due to the rarity of the condition. More studies are required to ascertain the role of trisomy 6 in the development of leukemia as well as in prognosis.

Keywords: Acute myeloid leukemia, Trisomy 6, Cytogenetics


Akut Miyeloid Lösemide Tek Bir Sitogenetik Anormallik Olarak Kromozom 6 Trizomisi

Monika  Gupta, Nita  Radhakrishnan, Manoranjan Mahapatra, Renu Saxena
All India Institute of Medical Sciences, Department of Hematology, New Delhi, India

Sitogenetik anormalliklerin tanımlanması lösemilerin tanı ve prognozunda önemli bir rol oynar. İzole trizomi 6, prognostik önemi iyi belirlenmemiş olan nadir bir anormalliktir. Tek sitogenetik anormallik olarak trizomi 6’ya sahip bir akut miyeloid lösemi (AML-M5 varyantı) olgusunu sunuyoruz. Trizomi 6 daha önce aplastik anemi, miyelodisplastik sendrom ve genellikle hiposelüler ilik ile ilişkilendirilmiş AML’de bildirilmiştir. Ancak hastamızın çok kısa bir geçmişi ve blastlar ile infiltre hiperselüler bir iliği vardı. Bu durumun nadirliği nedeni ile bu olguyu rapor ediyoruz. Hem lösemi gelişiminde trizomi 6’nın rolünü tespit etmek, hem de prognoz için daha fazla çalışma gereklidir.

Anahtar Kelimeler: Akut miyeloid lösemi, Trizomi 6, Sitogenetik


Monika  Gupta, Nita  Radhakrishnan, Manoranjan Mahapatra, Renu Saxena. Trisomy Chromosome 6 as a Sole Cytogenetic Abnormality in Acute Myeloid Leukemia. Turk J Hematol. 2015; 32(1): 77-79

Corresponding Author: Monika  Gupta, India


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