ISSN: 1300-7777 E-ISSN: 1308-5263
Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient [Turk J Hematol]
Turk J Hematol. 2007; 24(2): 85-87

Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient

Eren Gündüz, Olga Meltem Akay, Beyhan Durak, Zafer Gülbaş
Department Of Hematology, Osmangazi University Faculty Of Medicine, Eskişehir, Turkey

Therapy-related myelodysplastic syndrome in patients with acute promyelocytic leukemia is a rare event and the prognosis is poor. Allogeneic bone marrow transplantation is recently being reported as an effective treatment. We present a young patient with acute promyelocytic leukemia who developed myelodysplastic syndrome 52 months after complete remission. She underwent allogeneic peripheral blood stem cell transplantation but relapsed with biphenotypic leukemia after five months. To our knowledge, this is the first case to relapse with acute biphenotypic leukemia after allogeneic peripheral stem cell transplantation for therapy-related myelodysplastic syndrome following acute promyelocytic leukemia.

Keywords: Acute promyelocytic leukemia, therapy-related myelodysplastic syndrome, allogeneic peripheral blood stem cell transplantation, prognosis, biphenotypic leukemia


Aynı hastada gelişen akut promiyelositik lösemi sonrası miyelodisplastik sendrom ve kök hücre nakli sonrası bifenotipik lösemi

Eren Gündüz, Olga Meltem Akay, Beyhan Durak, Zafer Gülbaş
Hematoloji Bilim Dalı, Osmangazi Üniversitesi Tıp Fakültesi, Eskişehir, Türkiye

Akut promiyelositik lösemili hastalarda tedaviye bağlı miyelodisplastik sendrom nadir bir olaydır ve prognozu kötüdür. Son dönemde allogeneik kök hücre naklinin etkili bir tedavi şekli olduğu bildirilmektedir. Biz de tam remisyondan 52 ay sonra miyelodisplastik sendrom gelişen akut promiyelositik lösemili genç bir hastayı sunduk. Hastaya allogeneik kök hücre nakli yapıldı ancak 5 ay sonra bifenotipik lösemi gözlendi. Bildiğimiz kadarıyla bu olgu tedaviye bağlı miyelodisplastik sendrom nedeniyle yapılan allogeneik periferik kök hücre nakli sonrası bifenotipik lösemi şeklinde relaps gelişen ilk olgudur.

Anahtar Kelimeler: Akut promiyelositik lösemi, tedaviye bağlı miyelodisplastik sendrom, allogeneik periferik kök hücre nakli, prognoz, bifenotipik lösemi


Eren Gündüz, Olga Meltem Akay, Beyhan Durak, Zafer Gülbaş. Therapy-related myelodysplastic syndrome following acute promyelocytic leukemia and biphenotypic acute leukemia following stem cell transplantation in the same patient. Turk J Hematol. 2007; 24(2): 85-87

Corresponding Author: Eren Gündüz, Türkiye


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