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The Hemostatic Changes in Active Pulmonary Tuberculosis [Turk J Hematol]
Turk J Hematol. 2001; 18(2): 95-100

The Hemostatic Changes in Active Pulmonary Tuberculosis

Muzaffer Sezer1, Ahmet Öztürk1, Ahmet İlvan2, Mehmet Özkan2, Necdet Üskent1
1Department Of Hematology-oncology, Gata Haydarpaşa Training Hospital
2Department Of Tuberculosis, Gata Haydarpaşa Training Hospital, İstanbul, Turkey

Severe pulmonary tuberculosis (PTB) is sometimes complicated with deep venous thrombosis (DVT). We have examined the role of possible hemostat›c disturbance, which are predisposing factors for venous thrombosis in patients with PTB. Coagulation and platelet function tests have been studied in 40 patients with severe PTB and 40 healthy control volunteers before therapy and they were compared with 30th day results and
controls. Analysis in patients with active PTB showed anemia, leucocytosis, thrombocytosis, elevation in plasma fibrinogen, factor VIII, plasminogen activator inhibitor 1 (PAI-1) with depressed antithrombin III (ATIII) and protein C (PC) levels. On the 30th day of treatment, anemia, leucocytosis and thrombocytsis were improved. Fibrinogen and factor VIII levels decreased to normal levels, PC and AT III levels increased to normal levels whereas there was no difference in PAI-1 levels. Platelet aggregation studies demonstrated increased platelet activation. Activated protein C resistance was not determined. DVT was not detected in patients during the follow up period. Decreased AT III, PC and elevated plasma fibrinogen levels and increased platelet aggregation appear to induce hypercoagilable state seen in PTB and improves with tretament.

Keywords: Pulmonary tuberculosis, Hypercoagulable state, Protein C, Antithrombin III.

Muzaffer Sezer, Ahmet Öztürk, Ahmet İlvan, Mehmet Özkan, Necdet Üskent. The Hemostatic Changes in Active Pulmonary Tuberculosis. Turk J Hematol. 2001; 18(2): 95-100

Corresponding Author: Ahmet Öztürk, Türkiye

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Impact Factor (2017) = 0.650