ISSN: 1300-7777 E-ISSN: 1308-5263
Hematopoetic stem celi transplantation activity at a single center: Cerrahpaşa experience [Turk J Hematol]
Turk J Hematol. 2002; 19(2): 317-329

Hematopoetic stem celi transplantation activity at a single center: Cerrahpaşa experience

Zafer Başlar, Teoman Soysal, Burhan Ferhanoğlu, Şeniz Öngören, Ümit Üre, Yıldız Aydın, Birsen Ülkü, Gülten Aktuğlu, Nuran Akman
Division Of Hematology, Department Of Internal Medicine, Cerrahpaşa Medical School, University Of İstanbul, Turkey

At our institution 94 transplantations have been performed in an 8 year period up to December 2001. Forty-three females and 49 males with ages ranging from 14 to 61 years received 67 allogeneic (allo) and 27 autologous (auto) transplants; 2 patients were transplanted twice. The diagnosis of allo transplants were AML (27 patients-pts), CML (17 pts), ALL (16 pts) and AA (5 pts); those of auto transplants were NHL (13 pts), HD (10 pts), MM (3 pts) and AML (l pt). Of the patients with acute leukemia 69.7% were in first CR and ali but öne of the patients with CML were in first chronic phase. Source of hematopoetic stem cells were bone marrow (BM) in 61.9% (allo 81.5%, auto 14.8%) and peripheral blood (PB) in 38.1% (allo 18.5%, auto 85.2%). Ail donors were HLA-full matched siblings with öne exception. Conditionİng regimens were BU-CY (31 pts), TBI-CY (28 pts) and Flag-lda (öne pî) for leukemia, CY-ATG for AA, CBV for lymphoma and Mel-200 for MM. Median 2.69 x 108 nucieated celIsAg (BM) and 21.7 x 106 CD34 + celIsAg (PB) were infused to allo transplant recipients; 4 patients faiied to engraft and öne patient was inevaluable due to early death. Acute GVHD was observed in 11 patients (16.9% - grade ll-IV in 10.7%) and chronic GVHD was documented in 18 patients (33.9%- extensive in 9.43%). VOD was seen in 8 patients (12.3%). Early response was CR in 91.6% in patienîs wîth leukemia; patients with lymphoma showed a 73.1% response (CR & PR) rate and 23.1% had resistant disease. So far 27.6% of the patients have relapsed ör showed progression and 45.7% have died (disease-related 27.2%, transplant-related 18.5%). At a median follow-up time of 32 months (range 0.6-96) DFS is 50.8% and OS is 53.9% in the allo transplant group. With a shorter follow-up (median 16 months, range 1-65) the same figures for the auto transplant group are 51.9 and 55.5%, respectively, in this cohort overall, OS and DFS are significantly superior in patients with early-stage disease: 71.7% vs. 26.7% in advanced-stage disease for OS and 71.4% vs. 36.8% for DFS, respectively and this trend applies to both transplant groups (p< 0.001 for ali comparisons).

Keywords: Hematopoetic stem celi transplantation, Sİngle center study.


Zafer Başlar, Teoman Soysal, Burhan Ferhanoğlu, Şeniz Öngören, Ümit Üre, Yıldız Aydın, Birsen Ülkü, Gülten Aktuğlu, Nuran Akman. Hematopoetic stem celi transplantation activity at a single center: Cerrahpaşa experience. Turk J Hematol. 2002; 19(2): 317-329

Corresponding Author: Zafer Başlar, Türkiye


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