ISSN: 1300-7777 E-ISSN: 1308-5263
Congenital Agranulocytosis (Kostmann’s Syndrome) and G-CSF Therapy in an Infant [Turk J Hematol]
Turk J Hematol. 1999; 16(4): 171-175

Congenital Agranulocytosis (Kostmann’s Syndrome) and G-CSF Therapy in an Infant

Hanifi Soylu1, Ayşegül Ünüvar2, Nuran Üstün3, Fatih M. Mete3, Onur Kutlu1, Soner Sazak3, Ünsal Özgen1
1Department Of Pediatrics, Turgut Özal Medical Center, İnönü University, Malatya, Turkey
2Department Of Pediatrics Hematology-oncology, Faculty Of Medicine, İstanbul University İstanbul, Turkey
3Department Of Pediatrics, Vakıf Gureba Teaching Hospital, İstanbul, Turkey

Congenital agranulocytosis (Kostmann’s Syndrome) is a rare autosomal recessive inherited disorder characterised by severe neutropenia, recurrent infections, and death in early life, with the bone marrow showing a maturation arrenst of myeloid cells at the myelocyte stage. The treatment of Kostmann’s Syndrome with G-CSF results in rapid improvement. However, a few unexpected results with the use of G-CSF, were reported. Here, we describe a 7-month-old female with Kostmann’s Syndrome who had recurrent skin infections and a large pyogenic infection in the supravulvar region. The patient was treated with G-CSF successfully at low doses. The infectious process and the quality of lite of the patient improved. There was no adverse effect due to the dosage and the duration. Currently bone marrow transplantation is the best way to treat Kostmann’s Syndrome. Nevertheless, our experience showed that G-CSF treatment in Kostmann’s syndrome was highly effective and successfull on a short term basis.

Keywords: Kostmann’s Syndrome, Infant, G-CSF therapy.


Hanifi Soylu, Ayşegül Ünüvar, Nuran Üstün, Fatih M. Mete, Onur Kutlu, Soner Sazak, Ünsal Özgen. Congenital Agranulocytosis (Kostmann’s Syndrome) and G-CSF Therapy in an Infant. Turk J Hematol. 1999; 16(4): 171-175

Corresponding Author: Hanifi Soylu, Türkiye


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