ISSN: 1300-7777 E-ISSN: 1308-5263
Successful Off-Label Use of Recombinant Factor VIIa and Coil Embolization in an Adolescent with Massive Hemoptysis Due to Invasive Pulmonary Aspergillosis [Turk J Hematol]
Turk J Hematol. 2015; 32(1): 73-76 | DOI: 10.4274/tjh.2014.0347  

Successful Off-Label Use of Recombinant Factor VIIa and Coil Embolization in an Adolescent with Massive Hemoptysis Due to Invasive Pulmonary Aspergillosis

Dilek Gürlek Gökçebay1, Ali Fettah1, İsmail Kırbaş2, Bahattin Tunç1, Namık Yaşar Özbek1
1Ankara Children’s Hematology and Oncology Hospital, Clinic of Pediatric Hematology, Ankara, Turkey
2Turgut Özal University Faculty of Medicine, Department of Interventional Radiology, Ankara, Turkey

Invasive fungal infections have turned out to be a significant cause of morbidity and mortality in pediatric patients with malignant disorders. Massive hemoptysis, a rare complication of invasive pulmonary aspergillosis, may threaten the lives of patients, usually during the resolution of neutropenia. In this report, we describe a patient with massive hemoptysis due to invasive pulmonary aspergillosis whose bleeding was controlled successfully with off-label use of recombinant factor VIIa and subsequent coil embolization of the right pulmonary artery.

Keywords: Invasive pulmonary aspergillosis, Recombinant factor VIIa, Coil embolization, Children, Acute leukemia


İnvaziv Pulmoner Aspergillozise Bağlı Masif Hemoptizi Görülen Adölesan Bir Hastada, Endikasyon Dışı Rekombinan Faktör VIIa’nın ve Coil Emobolizasyonunun Başarılı Kullanımı

Dilek Gürlek Gökçebay1, Ali Fettah1, İsmail Kırbaş2, Bahattin Tunç1, Namık Yaşar Özbek1
1Ankara Children’s Hematology and Oncology Hospital, Clinic of Pediatric Hematology, Ankara, Turkey
2Turgut Özal University Faculty of Medicine, Department of Interventional Radiology, Ankara, Turkey

İnvaziv fungal enfeksiyonlar pediatrik malin hastalıklarda morbidite ve mortalitenin önemli bir nedenidir. Masif hemoptizi de sıklıkla nötropenin düzelme aşamasında görülen, invaziv pulmoner aspergillozisin hayatı tehdit edici nadir bir komplikasyonudur. Bu yazıda invaziv pulmoner aspergillozise bağlı masif hemoptizi gelişen bir hastada endikasyon dışı recombinant FVIIa kullanımı ardından sağ pulmoner artere coil embolizasyon uygulanarak kanama kontrolu sağlanan bir olgu sunulmuştur.

Anahtar Kelimeler: İnvasiv pulmoner aspergillozis, Recombinant factor VIIa, Embolizasyon, Çocuk, Akut lösemi


Dilek Gürlek Gökçebay, Ali Fettah, İsmail Kırbaş, Bahattin Tunç, Namık Yaşar Özbek. Successful Off-Label Use of Recombinant Factor VIIa and Coil Embolization in an Adolescent with Massive Hemoptysis Due to Invasive Pulmonary Aspergillosis. Turk J Hematol. 2015; 32(1): 73-76

Corresponding Author: Ali Fettah, Türkiye


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