ISSN: 1300-7777 E-ISSN: 1308-5263
Looking for Our Ten Years Results for Coronary Heart Disease and Ischemic Stroke Group for the Standpoint of Haemostasis [Turk J Hematol]
Turk J Hematol. 2002; 19(2): 255-263

Looking for Our Ten Years Results for Coronary Heart Disease and Ischemic Stroke Group for the Standpoint of Haemostasis

Turgut Ulutin1, Hüseyin Sönmez2, Nergis Domaniç3, Birsen İnce4, Çiğdem Bayram Gürel1, Dilek Ural3, Vural Ali Vural3, Hande Harmancı4, Ahmet Özaydın1, Erdal İnce1, Nur Buyru Sayhan1, Şükriye Yılmaz1, Gönül Kanıgür1, Emine Kökoğlu2
1Division Of Biomedical Sciences, Cerrahpaşa Medical Faculty, University Of İstanbul, Turkey
2Department Of Biochemistry, Cerrahpaşa Medical Faculty, University Of İstanbul, Turkey
3Department Of Cardiology, Cerrahpaşa Medical Faculty, University Of İstanbul, Turkey
4Department Of Neurology, Cerrahpaşa Medical Faculty, University Of İstanbul, İstanbul, Turkey

To evaluate the role the coagulation and fibrinolysis abnormalities in the pathogenesis of ischemic stroke of undetermined etiology, we assayed plasma concentration of fibrinopeptide-A and thrombin-antithrombin III complex, both sensitive markers for thrombin activation and fibrin formation, and D-dimer, a marker of plasmin activity and fibrinolysis. Hemostatic markers were measured in 32 patients with acute stroke and 20 patients with chronic stroke, and compared with 21 normal subjects. Fibrinopeptid-A and thrombin-antithrombin III complex levels were not elevated significantly, whereas the D-dimer level was markedly raised in acute (p< 0.001) and chronic (p< 0.05) phases of ischemic stroke in comparison with the control group. Prolonged elevation of D-dimer concentration suggests that hemostatic abnormalities have a primary role in the pathogenesis of ischemic stroke. The measurement of D-dimer concentration may help to better decide the indications for therapy of the patients with ischemic stroke of undetermined etiology.

Keywords: Hemostatic activation, Coronary artery disease, Molecular markers.


Turgut Ulutin, Hüseyin Sönmez, Nergis Domaniç, Birsen İnce, Çiğdem Bayram Gürel, Dilek Ural, Vural Ali Vural, Hande Harmancı, Ahmet Özaydın, Erdal İnce, Nur Buyru Sayhan, Şükriye Yılmaz, Gönül Kanıgür, Emine Kökoğlu. Looking for Our Ten Years Results for Coronary Heart Disease and Ischemic Stroke Group for the Standpoint of Haemostasis. Turk J Hematol. 2002; 19(2): 255-263, Türkiye


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