ISSN: 1300-7777 E-ISSN: 1308-5263
Tumour Necrosis Factor-Alpha Gene Polymorphism (-308 G-A) in Turkish Pediatric Thrombosis Patients [Turk J Hematol]
Turk J Hematol. 2002; 19(1): 39-41

Tumour Necrosis Factor-Alpha Gene Polymorphism (-308 G-A) in Turkish Pediatric Thrombosis Patients

Nejat Akar, Metis Hasipek
Department Of Pediatric Molecular Pathology And Genetics, Ankara, Turkey

Tumour necrosis factor-alpha (TNF-a) plays an important role in clot formation by activating platelets, monocytes and endothelial cells and inducing procoagulant substances such as negatively charged phospolipids or tissue factor. There is a genetically controlled inter-individual variation of TNF-a production. Carrying TNF2 allele could have a slight protective effect against the occurence of stroke in Sickle Cell Disease patients. We aimed to study this polymorphic site in Turkish children with the diagnosis of thrombosis.

Keywords: Tumour necrosis factor-alpha, Thrombosis.


Nejat Akar, Metis Hasipek. Tumour Necrosis Factor-Alpha Gene Polymorphism (-308 G-A) in Turkish Pediatric Thrombosis Patients. Turk J Hematol. 2002; 19(1): 39-41

Corresponding Author: Nejat Akar, Türkiye


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