ISSN: 1300-7777 E-ISSN: 1308-5263
Could Parvovirus B19 Induce a Rejection After Bone Marrow Transplantation in a Patient with Diamond-Blackfan Anemia? [Turk J Hematol]
Turk J Hematol. 2000; 17(3): 137-141

Could Parvovirus B19 Induce a Rejection After Bone Marrow Transplantation in a Patient with Diamond-Blackfan Anemia?

Nazan Sarper1, Nevin Yalman2, Sema Anak2, Hülya Bilgen2, Semra Özgenç2, Emine Can2, Gündüz Gedikoğlu2
1Department Of Pediatric Hematology-oncology, İstanbul Medical Faculty, İstanbul University, İstanbul, Turkey
2Our Children’s Leukemia Foundation Bmt Unit, İstanbul, Turkey

A four year-old-girl with Diamond-Blackfan anemia (DBA) that was resistant to corticosteroid treatment and transfusion dependent underwent (bone marrow transplantation) BMT from HLA identical sibling. The patient was conditioned with busulfan and cyclophosphamide and achieved complete marrow engraftment and mixed chimerism in DNA analysis. For the following 13 months she was not transfusion dependent and had a 100% Karnofsky score. But on the 14th month she had anemia ollowing fever, rash and enteritis. Parvovirus B19 IgM seropositivity confirmed Parvovirus infection. Although intravenous immunoglobulin was administered, bone marrow morphology and DNA analysis revealed rejection. Although mixed chimerism detected shortly after the BMT procedure might raise the possibility of an ongoing slow graft rejection during the relatively stable remission period, we think that parvovirus B19 had also contributed rejection.

Keywords: Parvovirus B19, Diamond-Blackfan anemia, Transplantation, Rejection.


Nazan Sarper, Nevin Yalman, Sema Anak, Hülya Bilgen, Semra Özgenç, Emine Can, Gündüz Gedikoğlu. Could Parvovirus B19 Induce a Rejection After Bone Marrow Transplantation in a Patient with Diamond-Blackfan Anemia?. Turk J Hematol. 2000; 17(3): 137-141

Corresponding Author: Nazan Sarper, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar


 



Impact Factor (2016) = 0.686