ISSN: 1300-7777 E-ISSN: 1308-5263
Homozygosity for the HR2 Haplotype: Is It a Risk Factor for Thrombosis? [Turk J Hematol]
Turk J Hematol. 2003; 20(4): 213-215

Homozygosity for the HR2 Haplotype: Is It a Risk Factor for Thrombosis?

Arzu Ulu, Erkan Yılmaz, Ece Akar, Nejat Akar
Department Of Pediatric Molecular Genetics, Ankara University Medical Faculty, Ankara, Turkey

A4070G (His 1299 Arg) polymorphism in exon 13 of factor V gene can influence factor V levels and contribute to the activated protein C resistance. We are presenting our data concerning Turkish population and postulate that homozygosity for the HR2 haplotype may be an important risk factor for thrombosis.

Keywords: Haplotype, HR2, Polymorphism, A4070G, Thromboembolism.


HR2 Haplotipi için Homozigotluk: Tromboz için bir risk faktörü mü?

Arzu Ulu, Erkan Yılmaz, Ece Akar, Nejat Akar
Department Of Pediatric Molecular Genetics, Ankara University Medical Faculty, Ankara, Turkey

HR2 haplotipinde bulunan A4070G (His 1299 Arg) polimorfizmi faktör V geninde yer alır ve plazma faktör V düzeylerini etkileyerek aktif protein C direncine yol açabilir. Bu çalışmada Türkiye verisi sunulmakta ve HR2 haplotipinde homozigotluğun tromboz için risk faktörü olabileceği hipotezi sunulmaktadır.

Anahtar Kelimeler: Haplotip, HR2, Polimorfizm, A4070G, Tromboembolizm.


Arzu Ulu, Erkan Yılmaz, Ece Akar, Nejat Akar. Homozygosity for the HR2 Haplotype: Is It a Risk Factor for Thrombosis?. Turk J Hematol. 2003; 20(4): 213-215

Corresponding Author: Nejat Akar, Türkiye


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